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1.
Vinod K. Ahirrao Rajiv A. Jadhav Suyog N. Vaidya Sachin S. Bhagwat Ravindra D. Yeole Mahesh V. Patel 《Biomedical chromatography : BMC》2022,36(6):e5354
Antibiotic susceptibility test (AST) discs are used as an in-vitro diagnostic tool to select the appropriate antibiotic to treat an infection. Generally, the concentration of the drug loaded on to the AST discs is measured by studying its activity against quality control organisms. This methodology has several limitations—it is time consuming, requires trained manpower, has a wider acceptance criteria of zone of inhibitions—causing ambiguity in judging smaller variations in drug concentration. To overcome these issues, we have developed and validated high-performance liquid chromatographic (HPLC) methods for the determination of strength of AST discs for in-house researched antibiotics, namely Levonadifloxacin/WCK 771, Nafithromycin/WCK 4873, Cefepime-Tazobactam/WCK 4282, and Cefepime-Zidebactam/WCK 5222. The drugs were extracted from the AST discs using an appropriate solvent. The developed methods are simple, accurate, precise, reproducible, rugged, and robust. They are efficient in terms of time, and can be easily conducted in a quality control laboratory during release as well as stability evaluation of AST disc. Application of HPLC methods for the determination of strength of AST discs ensures flawless quality and, consequently, a better selection of drugs to treat bacterial infections in clinics. 相似文献
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选择腰椎间盘突出症(LDH)患者60例,分为轻度退变组、中度退变组、重度退变组。患者均行MRI检查,比较3组的MRI参数,包括髓核(NP)区、纤维环(AF)区T2值。检测比较发现,3组LDH患者NP区、AF区T2值间存在明显差异,且与腰椎功能评分(JOA)呈正相关,与腰部疼痛评分(VAS)呈负相关(P<0.05)。NP区、AF区T2值联合鉴别轻中度、中重度椎间盘退变程度的AUC大于各指标单一鉴别,具有较高评估效能。因此,MRI参数评估LDH患者椎间盘退变程度方面具有良好价值,可为临床明确患者病情提供重要参考。 相似文献
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Poliana Cristina Spricigo Banny Silva Barbosa Correia Karla Rodrigues Borba Isabela Barroso Taver Guilherme de Oliveira Machado Renan Ziemann Wilhelms Luiz Henrique Keng Queiroz Junior Angelo Pedro Jacomino Luiz Alberto Colnago 《Molecules (Basel, Switzerland)》2021,26(12)
The cambuci is a native Brazilian fruit from the Atlantic Forest biome. A soft and astringent pulp, a green color, and a sweet aroma are its main characteristics. Classical food quality attributes (fresh fruit mass, fruit height, diameters, total soluble solid, titratable acidity, and ratio) and the metabolic profile from ten accessions from three different locations were analyzed herein by analytical methods (refractometry and neutralization titration) and nuclear magnetic resonance spectroscopy. Concerning sugar content, sucrose was the predominant compound, with glucose and fructose alternating in second, depending on the accession. Citric acid was the most relevant acid, followed by shikimic and quinic acids in quite variable amounts. These three main acids vary in amounts for each accession. Ascorbic acid content emerges as an important quality attribute and makes this fruit nutritionally attractive, due to values comparable to those contained in citric fruits. The main amino acids identified in cambuci were glutamic acid individually or in comprising the tripeptide glutathione (glutamic acid, cysteine, glycine). The quality diversity of the evaluated accessions suggests the potentiality of cambuci use in future breeding programs. 相似文献
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球-盘微动摩擦件磨损体积的测量与计算 总被引:7,自引:1,他引:7
一般地说,由于微动磨损量很小,测定非常困难,所得结果的误差通常都相当大.尽管几十年来人们对微动磨损进行了好些研究,然而至今却还没有建立起统一而完善的微动磨损量的测量和计算方法,以至很难对试验结果进行定量比较.因此,根据SRV微动磨损试验机的工作原理,利用几何和数学分析手段提出了一种能够比较精确地测量和计算球-盘接触型微动摩擦件磨损量的方法,并且利用不同的模型对计算方法进行简化,从而得出了球和盘的磨损体积计算公式。只要借助轮廓仪和读数显微镜测量出有关参数,就可以比较精确地计算出球和盘的微动磨损体积,为了验证这种计算方法的实用性和可靠性,还进行了52100钢对不同含钨量的Ni-W合金镀层的SRV微动磨损试验,测量结果与计算结果具有较好的一致性,由此可见,根据所提计算方法得到的计算结果,不仅可以增强SRV试验机测试结果的可比性,也为利用这种试验机深入开展微动磨损研究提供了参照依据。 相似文献
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目的 探讨腰椎Modic I型改变的腰椎终板与椎间盘髓核中TNF-α、IL-6、IL-8 的相关性。方法 收集30 例因下腰痛入院手术治疗并行腰椎MRI 检查确认为腰椎Modic I型改变患者的术中病灶椎间盘标本,进行免疫组化检测,并观察椎间盘组织病理变化及炎症因子的表达,IL-6、IL-8 相对表达水平以相对表达量△Ct 或(2-△Ct×104)进行分析。结果 Modic I型终板中TNF-α表达水平(9.2±0.7)高于髓核(7.2±0.5),差异有统计学意义(P<0.05);髓核中△Ct IL-6、△Ct IL-8 相对表达量(6.34±1.82、10.62±1.88)高于终板(4.07±1.86、5.92±1.31),差异均有统计学意义(均P<0.05)。结论 Modic I型终板中TNF-α、IL-6、IL-8的表达水平明显高于髓核,其引起下腰痛的原因主要为终板的炎症改变。 相似文献
7.
We announce a result on quantum McK ay correspondence for disc invariants of outer legs in toric Calabi–Yau 3-orbifolds, and illustrate our method in a special example [C3/Z5(1, 1, 3)]. 相似文献
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本文研究了欧拉圆盘运动过程中盘厚度以及盘面与水平面夹角α两因素对能量耗散的影响. 得出圆盘厚度与直径之比x对能量变化中各项因子的影响: x很小时, 质心在竖直方向上的动能变化和重力势能变化是系统能量耗散的主要因素; 当x>0.4142时, 圆盘绕与之平行的轴的转动动能变化成为主要因素, 并给出圆盘厚度可忽略的条件. 模拟了滚动摩擦、空气黏滞等不同能量耗散方式与x,α的关系, 导出各种耗散方式在圆盘运动的过程中的转变规律, 并指出x=0.1733, α>18°时能量耗散形式为纯滚动摩擦, 这修正了文献[26]结论. 相似文献
10.
Friction-induced vibration of a two-degree-of-freedom mass-damper-spring system interacting with a decelerating rigid strip
is investigated. The friction law is approximated by an analytical function to facilitate the analyses and numerical integrations.
It is shown that, after a quasi-harmonic transient period, accompanied by viscous energy dissipation, a short period of intensive
‘creep-slip’ vibration occurs, which generates a series of ‘micro-impacts’ on the strip. Because of the impulsive character
of such kind of loading, its Fourier spectrum is rich and quite broadband. Using an averaging technique, the ‘normal form’
equations of motion show that the out-of-phase vibration mode absorbs more energy from the decelerating strip when its natural
frequency satisfies certain resonance conditions. The study is then applied to an automotive disc brake model to gain useful
insight into the generation of squeal. It is shown that the out-of-phase creep-slip vibration (in the longitudinal direction)
of the brake pads generates an impulsive bending moment on the decelerating strip (disc rotor). This impulsive load may be
considered as a possible source for brake squeal. The technique developed in this paper may be extended to other ‘squealing
systems’ including models for geophysical faults (earthquakes). 相似文献